Pathologic Mechanical Stress and Endotoxin Exposure Increases Lung Endothelial Microparticle Shedding
نویسندگان
چکیده
منابع مشابه
Shear stress regulates endothelial microparticle release.
RATIONALE Endothelial activation and apoptosis release membrane-shed microparticles (EMP) that emerge as important biological effectors. OBJECTIVE Because laminar shear stress (SS) is a major physiological regulator of endothelial survival, we tested the hypothesis that SS regulates EMP release. METHODS AND RESULTS EMP levels were quantified by flow cytometry in medium of endothelial cells ...
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Microparticle release by vascular endothelium has been implicated in various cardiovascular pathologies. Ventilator-induced lung injury (VILI) is a life-threatening complication of mechanical ventilation at high tidal volumes associated with excessive mechanical stretch of pulmonary vascular endothelial cells. However, a role of VILI-relevant levels of cyclic stretch in microparticle generation...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2015
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2013-0347oc